Experimental Nephritis in Rats Induced by Injection of Anti-kidney Serum I. Preparation and Immunological Studies of Nephrotoxin* By

The etiology of the human disease, glomerulonephritis, remains unknown. Certain observations in this condition suggest that it may depend, in part at least, on a hyperergic state of the tissues. While various authors have attempted by different methods to produce experimental nephritis simulating the human affliction, only those investigations dealing with cytotoxins will be discussed. This communication presents a study of certain of the factors in the anti-organ sera responsible for the induction of renal abnormalities.